Nonfouling Polypeptide Brushes via Surface-initiated Polymerization of N(ε) -oligo(ethylene glycol)succinate-L-lysine N-carboxyanhydride.

نویسندگان

  • Jing Wang
  • Matthew I Gibson
  • Raphaël Barbey
  • Shou-Jun Xiao
  • Harm-Anton Klok
چکیده

This contribution describes the preparation of nonfouling polypeptide brushes via surface-initiated ring-opening polymerization of oligo(ethylene glycol) modified L-lysine N-carboxyanhydrides. Circular dichroism experiments indicated that these surface-anchored polypeptide chains assume an α-helical conformation, which does not change between pH 4 and 9. Furthermore, nonspecific adsorption of fluorescent labeled bovine serum albumin and fibrinogen on glass slides modified with these brushes was greatly reduced compared to unmodified glass substrates.

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عنوان ژورنال:
  • Macromolecular rapid communications

دوره 30 9-10  شماره 

صفحات  -

تاریخ انتشار 2009